Senior Research Associate, CMC Process Sciences
Department: 110 CMCLocation: Waltham, MA
Company Overview:
Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.
Role Summary:
The candidate will be responsible for internal process development of oligonucleotide conjugates and provide technical support for validation activities. This laboratory-based position will involve hands-on contributions to process establishment, process development, process characterization, and validation. The Senior Research Associate will collaborate with other functions within Dyne including, but not limited to, analytical method development, quality control, and platform research. The candidate will participate directly in pre-clinical development as well as activities directly related to process validation of Dyne’s clinical assets. The candidate is expected to be passionate about conjugate drug development and working in a dynamic environment.
This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.
Primary Responsibilities Include:
- Responsible for drug substance process development, including bioconjugation chemistry, purification, and formulation.
- Lead internal CMC Process Development activities via hands-on contribution in the lab
- Partner with Research to support bioconjugation development activities and enhance the tech transfer process to external manufacturing partners
- Represent CMC and Process Sciences as a technical leader in internal cross-functional teams
- Establish clear expectations and priorities, set objectives, and effectively apply resources to deliver on program goals
- Contribute creative ideas and new innovations that enable better products and processes.
Education and Skills Requirements:
- A bachelor’s or master’s degree in biology, biochemistry, chemistry, or similar related life science or engineering field is required
- A minimum of 3 years in Research & Development preferably in a clinical-stage biotechnology company
- Experience working with bioconjugates including a deep understanding of conjugation chemistries, preparative chromatography, and TFF is required
- Familiarity working with oligonucleotides including but not limited to antisense oligonucleotides, morpholino oligonucleotides, and siRNA is desired
- Hands on experience with analytical techniques for characterization of conjugates including HPLC/UPLC, SEC, SDS-PAGE, ion exchange chromatography, and UV/vis.
- Ability to challenge current processes, practices, and strategy to uncover alternative approaches, solutions, or methods
- Self-directed individual who is able to work effectively with limited direction in a complex, fast-paced environment
- Excellent interpersonal, organizational, negotiation, and communication skills; a team member than can work collaboratively with colleagues across functions
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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
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